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Nexium increases blood levels of diazepam (Valium) by decreasing the elimination of diazepam in the liver. Nexium and other PPIs reduce the absorption and concentration in blood of ketoconazole (Nizoral) and increase the absorption and concentration in blood of digoxin (Lanoxin). Co-administration of Nexium with Clarithromycin increaes area under the plasma concentration time curve (AUC) of the first. Nexium may slow down metabolism of such medications: citalopram, diazepam, clomipramine, phenytoin, imipramine. Consequently their dose should be corrected.
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